Mary Beth Mudgett  一键邀请

DrMudgett'slaboratorystudiesthebiochemicalmechanismsusedbybacterialpathogenstoalterplantphysiologyduringinfectionExtensivegeneticandphenotypicdataindicatethatthebacterialtypethreesecretion(T3S)systemanditsproteinsubstrates(referredtoasT3Seffectors)arethemajorvirulencedeterminantsthatpromotepathogencolonizationinplantsTheparadigmforT3SeffectorfunctionhasbeenthattheseproteinscollectivelysuppresshostdefenseresponsestopromotecolonizationanddiseaseprogressionThebiologicalfunction(s)ofmostT3Seffectors,however,isextremelylimitedandbiochemicalsupportforthisparadigmislackingThus,thegoalofDrMudgett'sresearchhasbeentoelucidateT3Seffectorfunction,identifyhosttargets,andprovidefundamentalknowledgeofhowperturbationofhostsignalingpathwaysleadstobacterialpathogenesisTodoso,thelabstudiestheT3SeffectorsinXanthomonascampestrispathovarvesicatoria(Xcv),thecausalagentofleafspotdisease