Giacomo Cavalli简介
GiacomoCavallistudiedBiologyatParmaUniversityinItaly,hetookhisPhDinnaturalsciencesattheETHZürich,Switzerlandin1994,anddidhispost-docinthelabofRenatoParo,attheUniversityofHeidelberg,Germany,from1995to1998In1999,hebecamejuniorgroupleaderatIGHinMontpellier,FranceIn2002,hewasmadeseniorPI,in2007hebecameheadoftheGenomeDynamicsdepartmentatIGHandhedirectedtheInstitutefrom2011to2014GiacomoCavallidiscoveredtransgenerationalinheritanceofchromatinstatesinmetazoanbyworkingonPolycombandTrithoraxgroupproteinsinDrosophiladuringhispostdocinthelabofRenatoParoTheCavallilabhasshownthatthe3DstructureofchromosomescanbeepigeneticallyheritableandthatitcontributestogenomeregulationFurthermore,theyprovidedthefirsthigh-resolutiondescriptionoftheprinciplesofgenomefoldinginmetazoansFinally,theCavallilabshowedthatPolycombproteinsregulatecellproliferationandhavetumorsuppressionactivityinflies