Peter K. Vogt简介
PeterKVogtProfessorofTheScrippsResearchInstitute,LaJolla,USAHeisanAmericanmolecularbiologist,virologistandgeneticistHisresearchfocusesonretrovirusesandviralandcellularoncogenesVogtreceivedhisundergraduateeducationinbiologyattheUniversityofWürzburgandin1959wasawardedhisPhDattheUniversityofTübingenforworkdoneattheMaxPlanckInstituteforVirologyinTübingenFrom1959to1962hewasDamonRunyonCancerResearchFellowinthelaboratoryofHarryRubinattheUniversityofCaliforniainBerkeleyandstartedworkonRoussarcomavirusHetaughtmicrobiologyandmolecularbiologytomedicalandgraduatestudentsattheUniversityofColoradoinDenver(1962–1967)andtheUniversityofWashingtoninSeattle(1967–1971)In1971,hejoinedtheUniversityofSouthernCaliforniaasHastingsProfessorofMicrobiologyandin1980assumedthechairmanshipoftheDepartmentofMicrobiologyattheSchoolofMedicineSince1993,hehasbeenaProfessoratTheScrippsResearchInstituteinLaJollaHebecameExecutiveVicePresidentandChiefScientificOfficeratScrippsin2012Atthebeginningofhisscientificcareer,Vogtstudiedmechanismsofretroviralcellentryandtheroleofviralsurfaceproteinsindetermininghostrange[8][9][10]HedefinedrelatedgroupsofviralsurfaceproteinsandtheircorrespondingreceptorsonthecellsurfaceDuringhistimeinSeattle,hisfocusshiftedtothegeneticsofretrovirusesTogetherwithhisassociateKumaoToyoshima,heisolatedthefirsttemperaturesensitivemutantsofaretrovirusandincollaborationwiththebiochemistPeterDuesbergdiscoveredthefirstretroviraloncogene,srcHisworkonmutantsoftheRoussarcomavirusenabledMichaelBishopandHaroldVarmustoisolateDNAsequencesthatrepresentthesrconcogeneandtodemonstratethecellularoriginofoncogenesInhisextensivestudiesonavianretroviruses,Vogtdiscoveredoncogenesthatplayimportantrolesinhumancancers,egmyc(incollaborationwithBisterandDuesberg),jun(withMakiandBos)andp3k(withChang)